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D that volatile solvents such as benzene, a main constituent of gasoline fuel, seems to interact with the synthesis and catabolism of catecholamines and serotonin in the brain, which might explain the neurotoxic effects of these solvents [53]. In this regard, deficiencies of serotonin or other monoamine neurotransmitters such as dopamine and norepinephrine are linked with depression [54,55]. In re
1
Ecules or to relative reduction in acetylcholinesterase-containing neurons, thus potentiating cholinergic effects. In the present study, no statistical differences were detected among the serotonin levels of the cerebral cortex in the three groups; the control, the leaded and the unleaded. However, in the hypothalamus, hippocampus, cerebellum, the serotonin level was lower in the groups exposed to
1
Ive behaviour in male rats.Parameter GROUP Tooth chattering Control Leaded gasoline Unleaded gasoline 1.2 ?0.33 3.7 ?0.63 a* 4 ?0.87 a* Number of aggression events Threat posture 1.1 ?0.31 3.9 ?0.43 a** 3.6 ?0.87 a* Leaping and biting 0.9 ?0.35 3.7 ?0.58 a** 3.4 ?0.70 a* Boxing position 0.8 ?0.25 2.7 ?0.47 a* 3.2 ?0.74 a**Values are expressed as means ?SE a: significantly different from the contro
1
Up as compared with the corresponding values of the control. Data presented in tables 3 show that the rats exposed to the two types of vapours encountered a significant decrease in the norepinephrine, dopamine and serotonin contents of the hippocampus as compared with the control group. On other hand, no significant changes were found in norepinephrine and serotonin between the leaded or the unlea
1
Ecules or to relative reduction in acetylcholinesterase-containing neurons, thus potentiating cholinergic effects. In the present study, no statistical differences were detected among the serotonin levels of the cerebral cortex in the three groups; the control, the leaded and the unleaded. However, in the hypothalamus, hippocampus, cerebellum, the serotonin level was lower in the groups exposed to
1
N male rats.Parameter Duration of aggression/sec GROUP Control Leaded gasoline Unleaded gasoline Tooth chattering 0.9 ?0.23 4.7 ?1.1 a** 4.4 ?0.92 a* Threat posture 1.5 ?0.54 6 ?1.2 a* 6.2 ?1.31 a* Leaping and biting 1.9 ?0.72 5.5 ?1.45 5.9 ?1.50 Boxing position 1 ?0.42 2.2 ?0.63 2.2 ?0.Values are expressed as means ?SE a: significantly different from the control group. Asterisks indicate the leve
1
Ither the leaded or unleaded group as compared with the control. On the contrary, dopamine was elevated in the cerebellum of leaded exposed group above both the unleaded gasoline and control. The fluctuations in the levels of dopamine in different brain areas may be related to the effects MMT which is an organic manganese (Mn) compound added to unleaded gasoline and the mechanisms of Mn neurotoxic
1
Ed as means ?SD a: significantly different from the control group. b: significantly different from the leaded gasoline. Asterisks indicate the level of significance (* P

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